Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship
نویسندگان
چکیده
منابع مشابه
New Aspect of Bone Morphogenetic Protein Signaling and Its Relationship with Wnt Signaling in Bone
Bone morphogenetic proteins (BMPs) were discovered and named in 1965 by Marshall Urist, who initially identified the ability of an unknown factor in bone to induce ectopic bones in muscle 1. In the last 45 years, the osteogenic function of BMPs has been extensively examined, mainly using osteoblasts in culture with exogenous treatments of BMPs 2. Based on their potent osteogenic abilities, clin...
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RNA processing involves a variety of processes affecting gene expression, including the removal of introns through RNA splicing, as well as 3' end processing (cleavage and polyadenylation). Alternative RNA processing is fundamentally important for gene regulation, and aberrant processing is associated with the initiation and progression of cancer. Deregulated Wnt signaling, which is the initiat...
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چکیده ندارد.
Wnt Signaling in Bone
Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases. Canonical Wnt signaling promotes mesenchymal progenitor cells to differentiate into osteoblasts. The canonica...
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Both Wnt signaling and heat shock proteins play important roles in development and disease. As such, they have been widely, though separately, studied. Here we show a link between a heat shock protein and Wnt signaling in a member of the basal phylum, Cnidaria. A heat shock at late gastrulation in the clonal marine hydrozoan, Hydractinia, interferes with axis development, specifically inhibitin...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2009
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.22009